Abuzzahab F.S. · Anderson B.J. Int Pharmacopsychiatry 1971;6:223–235https://doi.org/10.1159/000468273 ABSTRACT GET ARTICLE PDF LOGIN / REGISTER Abstract A total of 31 investigations involving 1,105 patients, on the effect of LSD in the treatment of alcoholics are reviewed. There were 13 single large-dose studies without controls, 5 such studies with controls, 4 studies of multiple low-dose LSD without controls,…
Author: Research
Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study
Michael P Bogenschutz, Alyssa A Forcehimes, Jessica A Pommy, …First Published January 13, 2015 Research Article Find in PubMed Article information Abstract Several lines of evidence suggest that classic (5HT2A agonist) hallucinogens have clinically relevant effects in alcohol and drug addiction. Although recent studies have investigated the effects of psilocybin in various populations, there have been no studies on the efficacy…
The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs
View Article Impact Front. Hum. Neurosci., 03 February 2014 | https://doi.org/10.3389/fnhum.2014.00020 Robin L. Carhart-Harris1*, Robert Leech2, Peter J. Hellyer2, Murray Shanahan3, Amanda Feilding4, Enzo Tagliazucchi5, Dante R. Chialvo6 and David Nutt1 1Division of Brain Sciences, Department of Medicine, Centre for Neuropsychopharmacology, Imperial College London, London, UK 2C3NL, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK 3Department of Computing, Imperial College…
The ethics of psychedelic research in disorders of consciousness
Andrew Peterson, Enzo Tagliazucchi, Charles WeijerNeuroscience of Consciousness, Volume 2019, Issue 1, 2019, niz013, https://doi.org/10.1093/nc/niz013Published: 09 October 2019 Article history PDF Split View Cite Permissions Icon Permissions Share Abstract This article provides an ethical analysis of psychedelic research involving disorders of consciousness patients. We apply two internationally accepted approaches for analyzing the ethics of human research, the Value-Validity Framework and Component…
Psychedelic Support
psychedelic.support Connect with a global network of health care professionals. Resource that helps individuals find qualified psychedelic providers. Qualified Providers are screened to assure deliverance of high quality and versatile services. They are licensed or have worked on psychedelic research studies. Experienced The Network specializes in diverse therapeutic modalities. Many are therapists or guides in…
Santa Cruz, California City Council Approves Decriminalization Measure Measure for Psychedelics
Santa Cruz, California is now the third city in the United States to decriminalized psychedelics. The measure passed on Tuesday, January 2020. View Resolution Link Resolution Reference List given to council members The measure states that the city should not utilize “resources in the investigation and arrest of persons twenty-one (21) years of age and…
Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers
Neiloufar Family, Emeline L. Maillet, Luke T. J. Williams, Erwin Krediet, Robin L. Carhart-Harris, Tim M. Williams, Charles D. Nichols, Daniel J. Goble & Shlomi Raz Psychopharmacology (2019)Cite this article 14k Accesses 231 Altmetric Metricsdetails Abstract Research has shown that psychedelics, such as lysergic acid diethylamide (LSD), have profound anti-inflammatory properties mediated by 5-HT2A receptor signaling, supporting their evaluation as…
Current perspectives on psychedelic therapy: use of serotonergic hallucinogens in clinical interventions
Albert Garcia-RomeuDepartment of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USACorrespondenceagarci33@jhmi.eduView further author information &William A. RichardsPages 291-316 | Received 23 Apr 2018, Accepted 04 Jun 2018, Published online: 13 Nov 2018 Abstract Humans have used serotonergic hallucinogens (i.e. psychedelics) for spiritual, ceremonial, and recreational purposes for thousands of years, but…
Sub-Acute Effects of Psilocybin on Empathy, Creative Thinking, and Subjective Well-Being
Natasha L. MasonDepartment of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The NetherlandsCorrespondenceNatasha.mason@maastrichtuniversity.nlhttp://orcid.org/0000-0001-7115-0389 , M.Sc., Ph.D. ,Elisabeth Mischler , Ph.D.,Malin V. Uthaug , M.Sc., Ph.D. &Kim P. C. Kuypers , Ph.D. Pages 123-134 | Received 23 Oct 2018, Accepted 18 Jan 2019, Published online: 26 Feb 2019 ABSTRACT Creative thinking and empathy are crucial for everyday…
The Associations of Naturalistic Classic Psychedelic Use, Mystical Experience, and Creative Problem Solving
Noah W. Sweat , B.S.,Larry W. Bates , Ph.D. &Peter S. Hendricks , Ph.D.Pages 344-350 | Received 25 May 2016, Accepted 08 Aug 2016, Published online: 08 Oct 2016 No ABSTRACT Developing methods for improving creativity is of broad interest. Classic psychedelics may enhance creativity; however, the underlying mechanisms of action are unknown. This study was designed to assess…
The experimental effects of psilocybin on symptoms of anxiety and depression: A meta-analysis
Highlights •Four trials testing psilocybin for anxiety and depression were meta-analyzed. • Within-group effects were large (Hedges’ gs = 1.16 to 1.47).• • Placebo-controlled effects were large (gs = 0.82 to 0.83) across three trials.• • Potential risk for bias was identified in several domains. Abstract The current meta-analysis examined the effects of psilocybin in combination with behavioral interventions on…
Psilocybin induces time-dependent changes in global functional connectivity: Psi-induced changes in brain connectivity
Abstract Background The use of Psilocybin in scientific and experimental clinical contexts has triggered renewed interest in the mechanism of action of psychedelics. However, its time-dependent systems-level neurobiology remains sparsely investigated in humans. Methods We therefore conducted a double-blind, randomized, counterbalanced, cross-over study during which 23 healthy human participants received placebo and 0.2 mg/kg of…
Ketamine Enhanced Psychotherapy: Preliminary Clinical Observations on Its Effectiveness in Treating Alcoholism.
Citation Kolp, E., Friedman, H. L., Young, M. S., & Krupitsky, E. (2006). Ketamine Enhanced Psychotherapy: Preliminary Clinical Observations on Its Effectiveness in Treating Alcoholism. The Humanistic Psychologist, 34(4), 399–422. https://doi.org/10.1207/s15473333thp3404_7 Abstract Ketamine is a dissociative anesthetic widely used by physicians in the United States and also a psychedelic drug that physicians can legally prescribe off-label within…
Biomedical analysis of New Psychoactive Substances (NPS) of natural origin.
AUTHORS: Alfredo Fabrizio Lo FaroAnnagiulia Di TranaNunzia La MaidaAdriano TagliabracciRaffaele GiorgettiFrancesco Paolo Busardò J Pharm Biomed Anal 2020 Feb 30;179:112945. Epub 2019 Oct 30. Department of Excellence of Biomedical Sciences and Public Health, University “Politecnica delle Marche” of Ancona, Via Tronto 71, Ancona, Italy. Electronic address:New psychoactive substances (NPS) can be divided into two main…
Psychedelics and the essential importance of context
Robin L Carhart-Harris, Leor Roseman, Eline Haijen, … First Published February 15, 2018 Research Article Find in PubMed https://doi.org/10.1177/0269881118754710 Article information Abstract Psychedelic drugs are making waves as modern trials support their therapeutic potential and various media continue to pique public interest. In this opinion piece, we draw attention to a long-recognised component of the…
Predicting Responses to Psychedelics: A Prospective Study
Eline C. H. M. Haijen1*, Mendel Kaelen1, Leor Roseman1,2, Christopher Timmermann1,2, Hannes Kettner1, Suzanne Russ3, David Nutt1, Richard E. Daws2, Adam D. G. Hampshire2, Romy Lorenz2 and Robin L. Carhart-Harris1 1Psychedelic Research Group, Neuropsychopharmacology Unit, Centre for Psychiatry, Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom 2The Computational, Cognitive and…
Biocatalytic Production of Psilocybin and Derivatives in Tryptophan Synthase‐Enhanced Reactions
Chemistry – A European Journal, 24(40), 10028-10031, July 2018https://doi.org/10.1002/chem.201801047 Authors Felix Blei – Friedrich Schiller University Jena Florian Baldeweg – Friedrich Schiller University Jena Janis Fricke – Friedrich Schiller University Jena 1 more Abstract Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is the main alkaloid of the fungal genus Psilocybe, the so-called “magic mushrooms.” The pharmaceutical interest in this psychotropic natural product as a future medication to treat depression…
Production Options for Psilocybin: Making of the Magic
Chemistry – A European Journal, 25(4), 897-903, January 2019https://doi.org/10.1002/chem.201802758 Authors Janis Fricke – Department Pharmaceutical Microbiology, Hans-Knöll-Institute Friedrich-Schiller-Universität, Beutenbergstrasse 11a, 07745, Jena, Germany Claudius Lenz – Department Pharmaceutical Microbiology, Hans-Knöll-Institute Friedrich-Schiller-Universität, Beutenbergstrasse 11a, 07745, Jena, Germany Jonas Wick – Department Pharmaceutical Microbiology, Hans-Knöll-Institute Friedrich-Schiller-Universität, Beutenbergstrasse 11a, 07745, Jena, Germany Abstract The fungal genus Psilocybe and other genera comprise numerous mushroom species that biosynthesize psilocybin…
Injury-Triggered Blueing Reactions of Psilocybe “Magic” Mushrooms.
Author information Department Pharmaceutical Microbiology, Hans-Knöll-Institute Friedrich-Schiller-Universität, Beutenbergstr. 11a, 07745, Jena, Germany. Synthetic Microbiology, Friedrich-Schiller-Universität, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute, Winzerlaer Str. 2, 07745, Jena, Germany. Department Biomolecular Chemistry, Leibniz, Institute for Natural Product Research and Infection Biology -, Hans-Knöll-Institute, Beutenbergstr. 11a, 07745, Jena, Germany. Abstract Upon injury, psychotropic…
Simultaneous Production of Psilocybin and a Cocktail of β-Carboline Monoamine Oxidase Inhibitors in “Magic” Mushrooms.
Blei F1, Dörner S1, Fricke J1, Baldeweg F1, Trottmann F2, Komor A2, Meyer F3, Hertweck C2,4, Hoffmeister D1. Author information 1Department Pharmaceutical Microbiology, Hans Knöll Institute, Friedrich Schiller University, Beutenbergstrasse 11a, 07745, Jena, Germany.2Department Biomolecular Chemistry, Leibniz Institute for Natural, Product Research and Infection Biology-Hans Knöll Institute, Beutenbergstrasse 11a, 07745, Jena, Germany.3Transfer Group Anti-Infectives, Leibniz Institute for Natural Product, Research and Infection Biology-Hans…
World’s first LSD microdosing study to be produced in New Zealand
Fifty-two years after LSD was outlawed in New Zealand, the University of Auckland is seeking the final approvals to study the effects of small doses of LSD on human health and wellbeing. University of Auckland associate professor Suresh Muthukumaraswamy, will be in charge of the study. The study will work with a group of 40…
Homological scaffolds of brain functional networks
Petri, Giovanni & Expert, Paul & Turkheimer, Federico & Carhart-Harris, Robin & Nutt, David & Hellyer, Peter & Vaccarino, Francesco. (2014). Homological scaffolds of brain functional networks. Journal of The Royal Society Interface. 11. 20140873. 10.1098/rsif.2014.0873. AbstractNetworks, as efficient representations of complex systems, have appealed to scientists for a long time and now permeate many…
Psilocin and Ketamine Microdosing: Effects of Subchronic Intermittent Microdoses in the Elevated Plus-Maze in Male Wistar Rats.
Behavioural Pharmacology Sep 2018 29(6) 530-536 Horsley, Rachel R.; Palenicek, Tomas; Kolin, Jan; Vales, Karel Abstract: Short-term moderate doses of serotonergic and dissociative hallucinogens can be useful in the treatment of anxiety, Recently, a trend has developed for long-term intermittent ‘microdosing’ (usually one-tenth of a ‘full’ active dose), with reports of long-lasting relief from anxiety…
Exploring the Effect of Microdosing Psychedelics on Creativity in an Open-Label Natural Setting.
Psychopharmacology Dec 2018 235(12) 3401-3413 Prochazkova, Luisa; Lippelt, Dominique P.; Colzato, Lorenza S.; Kuchar, Martin; Sjoerds, Zsuzsika; Hommel, Bernhard Bibliographies Other Resources: View Full Text Abstract: Taking microdoses (a mere fraction of normal doses) of psychedelic substances, such as truffles, recently gained popularity, as it allegedly has multiple beneficial effects including creativity and problem-solving performance,…
A Systematic Study of Microdosing Psychedelics.
LoS One Feb 2019 14(2) e1-e26 Polito, Vince; Stevenson, Richard J. Keywords psychedelicsstudymicrodosing Bibliographies Other Resources: View Full Text Abstract: The phenomenon of ‘microdosing’, that is, regular ingestion of very small quantities of psychedelic substances, has seen a rapid explosion of popularity in recent years. Individuals who microdose report minimal acute effects from these substances…
The Use of Imaging, Biomonitoring and Microdosing in Human Volunteers to Improve Safety Assessments and Clinical Development
Tal Burt, Robert D. Combes, in The History of Alternative Test Methods in Toxicology, 2019 4 Microdosing 4.1 Background Microdosing, or phase-0 clinical trials, is a regulatory pathway to first-in-human (FIH) studies that employs sub-therapeutic pharmacological exposures, to study the effects of novel drugs in humans. Microdosing is based on two main principles: first, that…
Preclinical Prediction of Human Pharmacokinetics
Malcolm Rowland, Robert L. Dedrick, in Principles of Clinical Pharmacology (Third Edition), 2012 Microdosing Microdosing is a recent, novel, and essentially empirical approach to human pharmacokinetic prediction, which has been made possible by the development of the ultrasensitive analytical techniques discussed in Chapter 12 [10]. It involves administering to humans a minute, safe, subpharmacologic dose…
Psychological and Cognitive Effects of Long-Term Peyote Use Among Native Americans
John H. Halperna,,Correspondence information about the author John H. HalpernEmail the author John H. Halpern, Andrea R. Sherwoodc, James I. Hudsona, Deborah Yurgelun-Toddb, Harrison G. Pope Jra Halpern, John H. et al.Biological Psychiatry, Volume 58, Issue 8, 624 – 631 Background Hallucinogens are widely used, both by drug abusers and by peoples of traditional cultures who ingest these substances…
Microdose Talks, Coaching and Retreats
Forest Medicine Coaching Ms. Sarah Hope: Instructor & Coach Empowered Conversations Around Psychedelics January 15 Online Event via WebinarDates: Wednesday, January 15, 2020Location: via ZoomCost: $60 Empowered Conversations Around Psychedelics For Parents and Guardians “We all know our children may be exposed to psychedelic substances at some point in high school or college. Research around…
Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms
Robin L Carhart-Harris, Leor Roseman, Mark Bolstridge, Lysia Demetriou, J Nienke Pannekoek, Matthew B Wall, Mark Tanner, Mendel Kaelen, John McGonigle, Kevin Murphy, Robert Leech, H Valerie Curran & David J Nutt Microdose JournalExecutive Brief:Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks….
Microdosing psychedelics: More questions than answers? An overview and suggestions for future research
Kim PC Kuypers, Livia Ng, David Erritzoe, … First Published July 14, 2019 Article Commentary Find in PubMed https://doi.org/10.1177/0269881119857204 Abstract Background: In the past few years, the issue of ‘microdosing’ psychedelics has been openly discussed in the public arena where claims have been made about their positive effect on mood state and cognitive processes such…
User perceptions of mental health consequences of hallucinogen use in self-identified spiritual contexts
PETTER GRAHL JOHNSTAD ABSTRACTAIMS – The article aims to gain insight into the private worlds of users of hallucinogenic drugs in spiritual contexts, with a focus on the self-perceived mental health implications of their practices. This will help us understand the rationale behind and consequences of hallucinogenic drug use. METHOD – Respondents were recruited at…
Powerful substances in tiny amounts: An interview study of psychedelic microdosing
Show all authors Petter Grahl JohnstadFirst Published February 15, 2018 Research Article https://doi.org/10.1177/1455072517753339 Abstract Aims: This article presents a qualitative interview study of people who microdose with psychedelic drugs, which means that the user takes about one tenth of an ordinary recreational dose. Design: Respondents (n = 21) were recruited at several Internet fora for…
The Past and Future of Psychedelic Science: An Introduction to This Issue
Journal of Psychoactive DrugsVolume 51, 2019 &Brad BurgePages 93-97 | Received 02 Apr 2019, Accepted 09 Apr 2019, Published online: 27 May 2019 Download citation https://doi.org/10.1080/02791072.2019.1606472 CrossMark The Past and Future of Psychedelic Science: An Introduction to This Issue ABSTRACT Psychedelic plants and fungi have been used in indigenous medicinal traditions for millennia. Modern psychedelic…
Sub-Acute Effects of Psilocybin on Empathy, Creative Thinking, and Subjective Well-Being
Natasha L. Mason , M.Sc., Ph.D. Elisabeth Mischler , Ph.D.,Malin V. Uthaug , M.Sc., Ph.D. &Kim P. C. Kuypers , Ph.D. Pages 123-134 | Received 23 Oct 2018, Accepted 18 Jan 2019, Published online: 26 Feb 2019 Download citation https://doi.org/10.1080/02791072.2019.1580804 Microdose Journal: Executive Brief Results indicated that psilocybin enhanced divergent thinking and emotional empathy the morning after use. Enhancements in convergent…
Conferences
Global Psychedelic Forum 21.06.2018 09:00 – 24.06.2018 18:00 PRAGUE, CZECH REPUBLIC GLOBAL PSYCHEDELIC FORUM Beyond Psychedelics is a global multidisciplinary forum on psychedelics, located in the Czech Republic; a country with a longstanding history of psychedelic research. Mission Discuss the potential of psychedelics, alternative states of consciousness and technologies for individuals and societies; review their risks…
A systematic study of microdosing psychedelics
Vince Polito , Richard J. Stevenson Published: February 6, 2019 https://doi.org/10.1371/journal.pone.0211023 Abstract The phenomenon of ‘microdosing’, that is, regular ingestion of very small quantities of psychedelic substances, has seen a rapid explosion of popularity in recent years. Individuals who microdose report minimal acute effects from these substances yet claim a range of long-term general health and…
Simultaneous Production of Psilocybin and a Cocktail of β-Carboline Monoamine Oxidase Inhibitors in “Magic” Mushrooms.
Chemistry. 2019 Nov 14. doi: 10.1002/chem.201904363. [Epub ahead of print] Blei F1, Dörner S1, Fricke J1, Baldeweg F1, Trottmann F2, Komor A2, Meyer F3, Hertweck C2,4, Hoffmeister D1. Author information 1Department Pharmaceutical Microbiology, Hans Knöll Institute, Friedrich Schiller University, Beutenbergstrasse 11a, 07745, Jena, Germany.2Department Biomolecular Chemistry, Leibniz Institute for Natural, Product Research and Infection Biology-Hans…
Potential Therapeutic Effects of Psilocybin.
Format: Abstract Neurotherapeutics. 2017 Jul;14(3):734-740. doi: 10.1007/s13311-017-0542-y. Johnson MW1, Griffiths RR2,3. Author information 1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. mwj@jhu.edu. 2Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.3Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA….
Psilocybin-assisted therapy for depression: How do we advance the field?
Aust N Z J Psychiatry. 2019 Nov 22:4867419888575. doi: 10.1177/0004867419888575. [Epub ahead of print] Meikle SE1, Liknaitzky P2, Rossell SL3, Ross M4, Strauss N5, Thomas N2,3, Murray G2,3, Williams M6, Castle DJ7,8. Author information 1Melbourne School of Psychological Science, The University of Melbourne, Melbourne, VIC, Australia.2School of Psychology, Deakin University, Burwood, VIC, Australia.3Centre for Mental…